City of Midland officials tell NewsWest 9, a pickup was hit from behind by a commercial truck due to traffic congestion.
The pick up was carrying 41-year-old Pedro Lara and 50-year-old Manuel Chavez were killed in the accident.
The driver of the other truck, 29-year-old Antonio Zapata Jr., was not seriously injured.
Traffic was backed up in the area for several hours.
Officials said that charges are pending and the investigation into the accident is continuing.